Azacitidine Combined with Cytarabine in Older Patients with Newly Diagnosed AML

Shijun Li ； Junyuan Qi ； Bo Jiang

《International Journal of Gerontology》 16卷1期 (2022/01) Pp. 57-59

https://doi.org/10.6890/IJGE.202201_16(1).0011

摘要

Azacitidine (AZA) combined with cytarabine was used for newly diagnosed older patients with acute myeloid leukemia (AML). Since 2017, 28 newly diagnosed older AML patients (＞ 65 years old) had received AZA combined with low dose cytarabine (LDAC) in our hospital. 9 patients (32%) achieved a CR, 7 (25%) achieved a CRi, and 10 (36%) achieved a PR for an ORR (CR+CRi+PR) rate of 93%. The median PFS and OS were 9.3 months (95% CI 7.55-11.05 months) and 12.6 months (95% CI 8.6-16.6 months), respectively. The 1-year PFS and 1-year OS were 31% and 50%, respectively. Post hoc univariate analysis showed that median OS was longer for patients with secondary AML (16.8 months) and WBC count ＜ 30 x 10^9/L at onset (16.7 months). AZA plus LDAC could obtain a better effect for the older AML patients ineligible for IC, and would be more suitable for older AML patients in China.

關鍵字

acute myelocytic leukemia ； elder patients ； treatment ； azacitidine ； low dose cytarabine