Because of impairment of both hearing and vision organs, the sensory input of deaf-blind people is often substituted by tactile sense. Currently, communication modes used by deaf-blind people in Taiwan are mainly either tactile fingerspelling or braille. However, most deaf-blind people have additional disabilities, such as intellectual disabilities or other types of disabilities. Therefore, the interpersonal interaction is particularly difficult for them. Most countries in Europe and in the United States have their tactile sign language. We need to develop a set of tactile sign language that is easy for us to understand and to learn, so as to facilitate deaf-blind students' communication skills. The researcher followed the design principles of tactile sign language in Europe and in the USA and developed tactile sign language in Taiwan. Totally, there are about 150 commonly used vocabularies in the set. It is hoped that deaf-blind people in Taiwan may benefit greatly from using this tool and their communication development will be promoted.