- 期刊
Research Progress on the Relationship between PI3K / Akt / mTOR Signaling Pathway and Autophagy in the Mechanism of Cerebral Ischemia-reperfusion Injury
摘要
Cerebral ischemia-reperfusion injury is a common and irreversible injury in the treatment of cardiovascular and cerebrovascular diseases. Modern medicine mainly treats ischemic nervous system diseases by regaining blood oxygen supply in ischemic region, and the resulting irreversible damage is lack of specific drugs in modern medicine. Phosphatidylinositol 3 kinase (PI3K) / protein kinase B (Akt) / rapamycin target (mTOR) signaling pathway is the main pathway of many signal transduction. In recent years, studies have found that PI3K / Akt / mTOR is involved in the pathological process of cerebral ischemia and plays a role in promoting survival and anti apoptosis. Activation of PI3K / Akt / mTOR signaling pathway can inhibit autophagy and play a neuroprotective role after cerebral ischemia. Therefore, based on PI3K / Akt / mTOR signal transduction pathway, the role and relationship between the signal pathway and autophagy in cerebral ischemia-reperfusion injury and their relationship will be studied in this paper, aiming to provide new ideas for the research of cerebral ischemia-reperfusion injury, so as to find accurate, efficient and targeted therapy.
參考文獻
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