Objective: Explore and discuss the application value of individualized nutritional care and behavioral intervention for patients with esophageal cancer radiotherapy. Methods: A total of 64 patients with esophageal cancer radiotherapy in our hospital from January 2020 to December 2020 were selected. According to the time of admission, they were divided into the study group (n=32) and the control group (n=32). The control group adopts conventional nursing, and the study group adopts individualized nutrition nursing and behavior intervention on the basis of the control group. Then, compare the nutritional status scores of the two groups [serum albumin (ALB), transferrin (TRF) levels], immune function [natural killer cells (NK), T lymphocyte subsets (CD4+)], and Piper Fatigue Score (PFS) for cancer‐related fatigue. Results: After 40Gy and 56Gy of radiotherapy, the levels of ALB and TRF in the study group were higher than those in the control group (P<0.05); After the intervention, the levels of NK and CD4+ in the study group were higher than those in the control group (P<0.05), while the PFS score of the study group was lower than that of the control group (P<0.05). Conclusion: The application of individualized nutritional care and behavioral intervention to patients with esophageal cancer radiotherapy can improve nutritional status, enhance immune function, and reduce cancer‐related fatigue.