Aiming at the problem of inaccurate monitoring data caused by the possible loss of radioactive aerosol in the pipeline due to adsorption and other factors in the radiation on‐line monitoring system of nuclear sites, combined with the actual situation, this paper uses FLUENT software to consider the flow and collision process of smokeless gas sol particles with different concentrations, different pipe bending angles and different kinds of inert particles in the pipeline, The aerosol pipeline flow model is established by simulation, the pipeline loss of uranium and plutonium aerosol is deduced, and its impact on radiation protection and nuclear emergency is analyzed. The results show that the loss rate of radioactive aerosols with different concentrations is similar and will become smaller and smaller after a long enough time, reaching 1.3 % after 100 s; The nuclear emergency shall be mainly considered in the project. The bend of the pipeline shall be close to 90° as far as possible. If the emergency response is to be made within 10 s, the emergency alarm threshold can be reduced by about 13 %.