Based on the collaboration data of research papers among cities in the Yangtze River Delta from 2005 to 2019, this paper analyzes the scientific research collaboration in the Yangtze River Delta. Firstly, the overall scientific research is reflected through the quantitative analysis of paper output and collaboration data. Secondly, the scientific research collaboration network is constructed by using the collaboration data of research papers between cities, and the network structure is analyzed by using the social network analysis method. It is found that the scientific research collaboration between cities in the Yangtze River Delta has been strengthened in recent years, but there are some problems such as unbalanced development.