Because the cable‐stayed bridge has the characteristics of beautiful appearance, strong spanning ability, flexible span arrangement and less construction interference, and has good mechanical properties and economic indicators. Therefore, since the 1950s, modern cable‐stayed bridges have developed very rapidly, with increasing spans and continuous technological advancement. However, due to the large span and high cost of the cable‐stayed bridge, once it is damaged in the earthquake, it will cause serious loss of life and property. Therefore, it is necessary to analyze the seismic capacity of the long-span cable‐stayed bridge. After the seismic waves are transmitted to the site where the bridge is located, a multi‐degree‐of‐freedom vibration system will be formed in which all parts of the bridge body participate. The Shangdi cable‐stayed bridge in the Jingbao Expressway project is a five‐span continuous single‐pylon single‐cable plane prestressed concrete cable‐stayed bridge. The ANSYS finite element analysis software is used to analyze the bearing capacity of the bridge under various working conditions, and the bridge An earthquake response analysis was performed. In the later stage, a series of checking calculations were carried out on the main beam. The analysis and verification show that the design calculation method is correct and the internal force distribution is reasonable, which meets the requirements of the design task.