Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties

Mie Nishimura ； Tatsuya Ohkawara ； Toshiyuki Kanayama ； Kazuya Kitagawa ； Hiroyuki Nishimura ； Jun Nishihira

《Journal of Traditional and Complementary Medicine》 5卷3期 (2015/07) Pp. 161-167

https://doi.org/10.1016/j.jtcme.2014.11.016

摘要

The extract from roasted chicory (Cichorium intybus L.; 菊苣jú jù) root (chicory root extract), which contains inulin-type fructans, has favorable effects including antihyperglycemic and antidyslipidemic effects and the improvement of bowel movement. In this study, we examined the effects of chicory root extract on blood glucose, lipid metabolism, and fecal properties in 47 healthy adult participants in a randomized, double-blind, placebo-controlled study. The participants were divided into a test group that drank chicory root extract and a placebo group that drank nonchicory root extract (ingesting 300 mL daily for 4 weeks). We performed hematological examinations and body composition measurements, and administered a visual analog scale (VAS) questionnaire for fecal properties at the baseline (Week 0) and after the intervention (Week 4) for the two groups. Although no significant differences in fasting plasma glucose or insulin were observed, hemoglobin A1c was found to decrease by ingesting chicory root extract. No intergroup differences in the levels of lipid metabolism parameters were observed. However, the level of adiponectin was significantly improved in the chicory root extract group when the baseline and postintervention values were compared. In addition, chicory root extract tends to improve the VAS score for fecal properties. These results suggest that chicory root extract could delay or prevent the early onset of diabetes mellitus and improve bowel movements.

關鍵字

fecal property ； glucose metabolism ； lipid metabolism ； roasted chicory root extract ； Hemoglobin A1c

參考文獻

Pereira AC, Floriano MS, Mota GF, Cunha RS, Herkenhoff FL, Mill JG, et al. Beta2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population. Hypertension. 2003;42:685-692.

Asakura R, Kametani N, Mitsuda H, Fukuhara I, Takahashi N, Takehara I. Effect of carbonated beverage containing resistant maltodextrin on the postprandial elevation of blood glucose level - a randomized double-blind crossover study. Jpn Pharmacol Ther. 2010;38:621-626.

Rosak C, Mertes G. Effects of acarbose on proinsulin and insulin secretion and their potential significance for the intermediary metabolism and cardiovas-cular system. Curr Diabetes Rev. 2009;5:157-164.

Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA1c. Diabetes Care. 2003;26:881-885.

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8:1288-1295.