Clinical efficacy and tolerability of two Japanese traditional herbal medicines, Hachimi-jio-gan and Gosha-jinki-gan, for lower urinary tract symptoms with cold sensitivity

Hiroshi Yagi ； Ryo Sato ； Kojiro Nishio ； Gaku Arai ； Shigehiro Soh ； Hiroshi Okada

《Journal of Traditional and Complementary Medicine》 5卷4期 (2015/10) Pp. 258-261

https://doi.org/10.1016/j.jtcme.2015.03.010

摘要

We evaluated the efficacy and tolerability of Hachimi-jio-gan (HJG; 八味地黃丸bā wèi dì huáng wán) and Gosha-jinki-gan (GJG; 濟生腎氣丸jì shēng shèn qì wán), two traditional Japanese medicines, in 60 patients with lower urinary tract symptoms (LUTS) having cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. All patients received a mixture of HJG or GJG for 12 weeks in addition to α1-blockers or antimuscarinic drugs as add-on therapy. International Prostate Symptom Score, International Prostate Symptom Score-Quality of Life, Benign Prostatic Hyperplasia Impact Index, and the number of nocturnal voids were statistically much improved. However, there was no change in maximal urinary flow rate and post-void residual urine. Urinary 8-hydroxy-2-deoxyguanosine was statistically greatly improved from baseline after treatment in the HJG group compared to the GJG group. Adverse reactions were observed in 8.3% of patients, but all reactions were mild. Both HJG and GJG mixtures can serve as safe and effective potential therapeutic alternatives in patients with LUTS and cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. Additionally, HJG mixture was found to have anti-oxidative activity, and therefore further long-term clinical investigations are needed to examine its anti-aging effects in addition to its effect on urinary symptoms.

關鍵字

Hachimi-jio-gan ； Gosha-jinki-gan ； Cold sensitivity ； Oxidative stress ； Lower urinary tract symptoms

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