Evaluation of the anti-inflammatory activity of the aqueous and ethanolic extracts of the leaves of Albizzia lebbeck in rats

Girish Gulab Meshram ； Anil Kumar ； Waseem Rizvi ； C. D. Tripathi ； R. A. Khan

《Journal of Traditional and Complementary Medicine》 6卷2期 (2016/04) Pp. 172-175

https://doi.org/10.1016/j.jtcme.2014.11.038

摘要

Albizzia lebbeck Benth. (Mimosaceae) is a medicinal tree used to treat several inflammatory ailments in the Indian traditional Ayurvedic system of medicine. The aim of the present study was to evaluate the possible anti-inflammatory activity of the aqueous (AE) and ethanolic (EE) extracts of the leaves of A. lebbeck to support the ethnopharmacological claims. The study was carried out using Wistar rats (100-150 g). The AE and EE were prepared using the Soxhlet extraction process. The anti-inflammatory activity of the AE and EE of the leaves of A. lebbeck were studied using carrageenan-induced paw edema and cotton pellet-induced granuloma models. The AE and EE of the leaves of A. lebbeck at doses of 50, 100, and 200 mg/kg p.o. (oral administration) showed a dose-dependent and significant (p ＜ 0.05) inhibition of carrageenan-induced hind paw edema with maximum percentage inhibition (PI) values of 22.34, 30.85, 39.36 and 22.53, 32.98, 42.55, respectively. The AE and EE at doses of 50, 100, 200 mg/kg p.o. significantly (p ＜ 0.05) inhibited granuloma formation with PI values of 19.07, 27.57, 38.55 and 23.93, 32.23, 42.33, respectively. The AE and EE of the leaves of A. lebbeck showed significant (p ＜ 0.05) anti-inflammatory activity.

關鍵字

Albizzia lebbeck leaves ； Carrageenan ； Cotton pellet ； Percentage inhibition ； Anti-inflammatory

參考文獻

Grosser T, Smyth E, Fitzgerald GA. Goodman and Gilman's the pharmacological basis of therapeutics. In: Brunton L, ed. Anti-inflammatory, Antipyretic and Analgesic Agents: Pharmacotherapy of Gout. 12th ed. New York, NY: McGraw-Hill; 2011:959-1000.

Chorousus GP. Basic and clinical pharmacology. In: Katzung BG, Masters SB, Trevor AJ, eds. Adrenocorticosteroids and Adrenocortical Antagonists. 12th ed. New York, NY: McGraw-Hill; 2012:697-711.

Ayurvedic Pharmacopoeia Committee. Department of AYUSH, Ministry of Health and Family Welfare, Government of India. Ayurvedic Pharmacopoeia of India. New Delhi: Controller of Publications; 2001.

Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Allahabad: Panini Office Indian Press; 1919.

Nadkarni KM. Indian Materia Medica. 3rd ed. Mumbai: Bombay Popular Prakashan; 1982.