Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization

Masaaki Minami ； Toru Konishi ； Zhixia Jiang ； Tetsuya Arai ； Toshiaki Makino

《Journal of Traditional and Complementary Medicine》 6卷3期 (2016/07) Pp. 252-256

https://doi.org/10.1016/j.jtcme.2015.06.001

摘要

Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; 辛夷清肺湯xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine (日本漢醫rì běn hèn yī) and traditional Chinese medicine (TCM;中醫zhōng yī), has been used for the treatment of chronic sinusitis. The objective of this study was to evaluate the anti-allergic effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization using ovalbumin (OVA) as an antigen. Extract of shin'iseihaito (SSHT) could reduce the eosinophil, serum IgE and interleukin (IL)-4 levels, while increased the interferon (IFN)-γ levels in allergic mouse. Furthermore, allergic-murine serum treated with SSHT could not activate passive cutaneous anaphylaxis (PCA) reaction in murine model. Thus, our study showed that SSHT may possess anti-allergic activity. We suggested that SSHT may contribute to inhibit the exacerbation of allergic reaction induced by nasal sensitization.

關鍵字

Shin'iseihaito ； IgE ； Interleukin-4 ； Interferon-γ ； Passive cutaneous anaphylaxis reaction

參考文獻

Yen HR, Sun MF, Lin CL, Sung FC, Wang CC, Liang KL. Adjunctive traditional Chinese medicine therapy for patients with chronic rhinosinusitis: a population-based study. Int Forum Allergy Rhinol. 2014. http://dx.doi.org/10.1002/alr.21466

Wang T, Huang H, Ahang Y, et al. Role of effective composition on antioxidant, anti-inflammatory, sedative-hypnotic capacities of 6 common edible Lilium varieties. J Food Sci. 2015. http://dx.doi.org/10.1111/1750-3841.12787

McCusker C, Chicoine M, Hamid Q, Mazae B. Site-specific sensitization in a murine model of allergic rhinitis: role of the upper airway disease in lower airway disease. J Allergy Clin Immunol. 2002;110:891-898.

Yamamoto K, Kawamura I, Tominaga T, Nomura T, Ito J, Mitsuyama M. Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice. Clin Exp Immunol. 2006;144:475-484.

Okano M, Azuma M, Yoshino T, et al. Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice. Am J Respir Crit Immunol. 2001;164:1501-1507.