Medicinal and health benefit effects of functional sea cucumbers

Ratih Pangestuti ； Zainal Arifin

《Journal of Traditional and Complementary Medicine》 8卷3期 (2018/07) Pp. 341-351

https://doi.org/10.1016/j.jtcme.2017.06.007

摘要

Sea cucumbers have long been used as food and traditional medicine in Asian countries with Stichopus hermanni, Thelenota ananas, Thelenota anax, Holothuria fuccogilva, and Actinopyga mauritiana as most highly-valued species. These organisms are potential source of high value-added compounds with therapeutic properties such as triterpene glycosides, carotenoids, bioactive peptides, vitamins, minerals, fatty acids, collagens, gelatins, chondroitin sulfates, amino acids. In the recent years, health benefit effects of sea cucumbers have been validated through scientific research and have shown medicinal value such as wound healing, neuroprotective, antitumor, anticoagulant, antimicrobial, and antioxidant. These functional materials lead to potential development in various foods and biomedicine industries. In this review, we have presented a general view of major medicinal and health benefit effects of functional sea cucumbers from Asia region. The structural significance and the potential application of sea cucumber-derived functional materials as well as their nutritional value are also discussed.

關鍵字

Sea cucumber ； Medicinal ； Health ； Functional ； Materials

參考文獻

Wu M, Xu S, Zhao J, Kang H, Ding H. Physicochemical characteristics and anticoagulant activities of low molecular weight fractions by free-radical depolymerization of a fucosylated chondroitin sulphate from sea cucumber Thelenata ananas. Food Chem. 2010;122(3):716-723.

Wu M, Xu S, Zhao J, Kang H, Ding H. Free-radical depolymerization of glycosaminoglycan from sea cucumber Thelenata ananas by hydrogen peroxide and copper ions. Carbohydr Polym. 2010;80(4):1116-1124.

Huang N, Wu M-Y, Zheng C-B, Zhu L, Zhao J-H, Zheng Y-T. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry. Carbohydr Res. 2013;380:64-69.

Luo L, Wu M, Xu L, et al. Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers. Mar Drugs. 2013;11(2):399-417.

Gao N, Lu F, Xiao C, et al. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. Carbohydr Polym. 2015;127:427-437.