Antidiabetic potential of Asparagus racemosus Willd leaf extracts through inhibition of α-amylase and α-glucosidase

R. Vadivelan ； R. Gopala Krishnan ； R. Kannan

《Journal of Traditional and Complementary Medicine》 9卷1期 (2019/01) Pp. 1-4

https://doi.org/10.1016/j.jtcme.2017.10.004

摘要

The aim of this work was to evaluate the inhibitory activities of different extracts of Asparagus racemosus Willd on α - amylase and α - glucosidase at varying concentrations. Diabetes mellitus is a clinical condition characterized by hyperglycaemia in which an elevated amount of glucose circulates in the blood plasma. α - amylase and α - glucosidase inhibitors are used to achieve greater control over hyperglycemia in type 2 diabetes mellitus. This study is to treat the diabetes using natural resources. We aimed to evaluate of Asparagus racemosus Willd by digestive enzymes inhibitory activity. n-hexane, chloroform, ethyl acetate, methanol, and aqueous was used to extract the root of the Asparagus racemosus Willd. The different extracts were then used to study its digestives enzymes activity α-amylase and α - glucosidase inhibitory activity. The significant inhibitory effect of α-amylase and α- glucosidase enzyme and exhibited lower inhibitory activity than acarbose was extracted by the ethyl acetate and aqueous extracts of the plant. Flavonoids, Tannins and phenolic, Saponins, Amino acids, Protein are the major phytochemical constituents present. The total flavonoid content plant extracts of ethyl acetate and aqueous showed dose dependent 23.45 ± 1.33 mg rutin equivalent/g and 25.81 ± 0.82 mg rutin equivalent/g respectively. The total triterpenoids content plant extracts of ethyl acetate, aqueous showed dose dependent 109.8 ± 5.6 mg ursolic acid/g and 95.6 ± 7.5 mg ursolic acid/g respectively. The antidiabetic potential and to develop medicinal preparations and nutraceuticals and function foods for diabetes has revealed.

關鍵字

Asparagus racemosus Willd ； Diabetes mellitus ； α-amylase ； α-glucosidase

參考文獻

Lin Chang Chia, San Lin Che, Lai Guia Hung. Phytochemical characteristics, free radical scavenging activities, and neuroprotection of FiveMedicinal plant extracts. Evidence-Based Complementary and AlternativeMedicine. 2012. https://doi.org/10.1155/2012/984295

Matsui T, Tanaka T, Tamura Toshima A, Miyata Y, Tanaka K, et al. Alphaglucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem. 2007;55:99-105.

Bhandari MR, Nilubon JA, Gao, Kawabata J. a -Glucosidase and a amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergeniaciliata Haw.). Food Chem. 2008;106:247-252.

Kao YH, Chang HH, Lee MJ, Cheng CL. Tea, obesity and diabetes. Mol Nutr Food Res. 2006;50(2):188-210.

Kumar A, Ram J, Samarth RM, Kumar M. Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice. Phytomedicine. 2005;12:285-293.