The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

Introduction: As of March 11th, 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Articles published after the SARS-CoV-1 (2002) epidemic suggest that the use of an herbal-drug integrative medical approach could have contributed to a lower fatality rate and a more rapid response in controlling the outbreak. Methods: Pubmed was searched for articles that investigated the antiviral properties and mechanisms of action of herbs or natural compounds against the SARS-coronavirus (CoV). Results: Forty-three (43) relevant papers were located. A general count rendered 450þ herbs and natural compounds with antiviral properties against the SARS-CoV and related viruses. From the 43 articles, thirty-one (31) uncovered the mechanisms of action of the natural substances able to oppose the coronavirus. Discussion: A series of herbs and natural compounds demonstrated moderate to strong antiviral activity. Research on many herbs-natural compounds also showed potent and significant inhibition of CoV-host protein pathways responsible for different phases of viral replication specifically targeting 3CL^(PRO), PL^(PRO), RdRp, helicase protein, S protein, N protein, 3a protein, Cathepsin L, Nsp1, Nsp3c, and ORF7a, and the S protein/ACE-2 interaction. Conclusion: The herbs-natural compounds with antiviral activity and that caused inhibition/blockade of the CoV-host protein pathways are potential therapeutic candidates. The homology between the SARS-CoV- 1 and SARS-CoV-2 is around 80%. Thus, effective herbs-compounds for the former would likely be beneficial for the latter also depending on target protein similarities between the viruses. Here we provide the mechanistic bases supporting an integrative approach that includes natural compounds to fight coronavirus infections.

關鍵字

Coronavirus ； COVID-19 ； Herbs ； Natural compounds ； Antiviral ； Pandemic

參考文獻

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被引用紀錄

Vardhan, S., & Sahoo, S. K. (2022). Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations. Journal of Traditional and Complementary Medicine, 12(1), 44-54. https://doi.org/10.1016/j.jtcme.2021.12.002

Vidoni, C., Fuzimoto, A., Ferraresi, A., & Isidoro, C. (2022). Targeting autophagy with natural products to prevent SARS-CoV-2 infection. Journal of Traditional and Complementary Medicine, 12(1), 55-68. https://doi.org/10.1016/j.jtcme.2021.10.003

Singh, R., Bhardwaj, V. K., Sharma, J., Purohit, R., & Kumar, S. (2022). In-silico evaluation of bioactive compounds from tea as potential SARS-CoV-2 nonstructural protein 16 inhibitors. Journal of Traditional and Complementary Medicine, 12(1), 35-43. https://doi.org/10.1016/j.jtcme.2021.05.005

Zaki, A. A., Ashour, A., Elhady, S. S., Darwish, K. M., & Karmalawy, A. A. A. (2022). Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies. Journal of Traditional and Complementary Medicine, 12(1), 16-34. https://doi.org/10.1016/j.jtcme.2021.05.001

Vardhan, S., & Sahoo, S. K. (2022). Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells. Journal of Traditional and Complementary Medicine, 12(1), 6-15. https://doi.org/10.1016/j.jtcme.2021.04.001

延伸閱讀

周芸瑄（2021）。To Explore the Possible Factors Affecting the Confirmed Rate , Death Rate and Recovery Rate of Coronavirus Disease 2019 (COVID-19)〔碩士論文，淡江大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0002-3006202112564200
楊易靜（2005）。Study of traditional Chinese medicines and Taiwanese herbs for biological activities against coronavirus (human coronavirus 229E and SARS coronavirus ) and inflammation〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2903200614043338
黃靖鈞、吳孟珊、陳忠仁（2020）。Exploring the Progression and Treatment Prospects of Coronavirus Disease 2019 (COVID-19) with the Integration of Traditional Chinese and Western Medicine。中醫藥研究論叢，23(2)，93-115。https://doi.org/10.6516/TJTCM.202009_23(2).0007
Huang, Y. H. (2021). Caring the Human lives in the Age of Global Pandemic, Covid-19 From Globalization to Localization: Coronavirus and the Excluded. 佛光人文學報, (4), 107-144. https://www.airitilibrary.com/Article/Detail?DocID=P20210624001-202101-202106240020-202106240020-107-144
陳怡瑄（2022）。The relationships between coronavirus pandemic anxiety, technology anxiety, and learning satisfaction in distance learning among middle-aged adults during the Covid-19 pandemic: The moderating effects of extraversion, openness to experience, and social support〔碩士論文，國立臺灣師範大學〕。華藝線上圖書館。https://doi.org/10.6345/NTNU202201470

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The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

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