Role of gut microbiota metabolism and biotransformation on dietary natural products to human health implications with special reference to biochemoinformatics approach

Mohd Hafizur Rehman Ansari ； Sadia Saher ； Rabea Parveen ； Washim Khan ； Imran Ahmad Khan ； Sayeed Ahmad

《Journal of Traditional and Complementary Medicine》 13卷2期 (2023/03) Pp. 150-160

https://doi.org/10.1016/j.jtcme.2022.03.005

摘要

Gut microbiota contributes to diverse mammalian processes including the metabolic functions of drugs. It is a potential new territory for drug targeting, especially for dietary natural compounds such as tannins, flavonoids, steroidal glycosides, anthocyanins, lignans, alkaloids, and others. Because most herbal medicines are orally administered, the chemical profile and corresponding bioactivities of herbal medicines may be altered and implication to ailments by specific microbiota through gut microbiota metabolisms (GMMs) and gut microbiota biotransformations (GMBTs). In this review, briefly introducing the interactions between different categories of natural compounds and gut microbiota produced countless microbial degraded or fragmented metabolites with their biological significance in rodent-based models. From natural product chemistry division, thousands of molecules are produced, degraded, synthesized, and isolated from natural sources but exploited due to lack of biological significance. In this direction, we add a Bio-Chemoinformatics approach to get clues of biology through a specific microbial assault to (Natural products) NPs.

關鍵字

Gut microbiota ； Dietary natural compounds ； Gut-microbial diversity ； Mutualism strategies ； GMM-GMBTs reactions ； Bio-chemoinformatics ； Gut microbiota-interplay disorders

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