In this paper, based on the target response spectrum of seismic load, using the seismic record search engine of peer seismic database, the characteristic parameters of seismic load for the seismic analysis of vacuum rupture valve engineering structure are obtained as the transient dynamic load for the research of seismic performance analysis. Meanwhile, the time history (transient) analysis method and peer seismic data separation principle are applied, and ANSYS is used The transient dynamic Newmark - β analysis and calculation module of workbench software is used to analyze and calculate the stress-strain and its variation law of the vacuum breaking valve installation structure. The results show that the maximum equivalent stress of the valve occurs at the lower neck of the valve body at 0.22s after the earthquake, where the membrane stress is 0.53mpa, the membrane + bending stress is 1.14mpa, and the maximum deformation is 0.0053mm. According to JB According to 4732-2005 "steel pressure vessels - Analysis and design standard", the vacuum rupture valve meets the requirements of seismic performance design. The selection and determination of seismic load and the transient dynamic analysis method for seismic performance of engineering structure are adopted, which provides a reference for the seismic performance analysis and research of thermal power / nuclear boiler equipment and components in the future.