Retrosynthetic analysis is a problem solving method for designing a synthetic pathway. Retrosynthetic analysis is a series of transformations that eventually simplifies the synthetic target molecule into numerous simple and commercially available compounds called starting materials. Retrosynthesis, the reverse process of a chemical synthesis, is accomplished by simplification and transformation depending on the existing chemical reactions. After each step of retrosynthetic analysis, the simplified precursor structure is alternatively became the target molecule. In this paper, the author will outlines several retrosynthetic analysis strategies and summarizes basics of retrosynthesis with simple examples to illustrate the strategies' possible application. In general, the retrosynthetic analysis can be simplified into four groups: common atom approach, one group disconnection, two groups disconnection, and illogical disconnection. A good retrosynthetic analysis should have good mechanism, achieve the greatest possibility of simplification, employ maximum convergence, and result in recognizable starting materials. Retrosynthetic analysis can lead to many synthetic routes and explores the optimal route for industrial manufacturing.