Inhibition of Amyloid-β Induced Signaling as an Approach to Prevent Neurofibrillary Tangle Formation and Cure Alzheimer's Disease

Zhanghan Ni ； Hailun Dong

《International Core Journal of Engineering》 7卷1期 (2021/01) Pp. 195-200

https://doi.org/10.6919/ICJE.202101_7(1).0026

摘要

Alzheimer's Disease is a devastating neurodegenerative disease and is the most prevalent cause of age-related dementia worldwide. Numerous resources are invested in the development therapies based on the removal of amyloid-beta plaque; however, insignificant results are yielded in late-stage clinical trials. Here we propose a treatment for AD through the inhibition of amyloid-beta (Aβ) oligomers induced signaling pathway, which prevents the phosphorylation of tau protein and the formation of neurofibrillary tangle, a pathologic hallmark of AD. High-throughput screening and mouse trials are respectively designed for binding inhibitor discovery and behavioral testing. The results of the experiments will provide important data regarding the potential chemicals for the inhibition of amyloid-beta (Aβ) oligomer binding and their effectiveness in AD treatment.

關鍵字

Alzheimer's Disease ； Tau protein ； Amyloid-beta oligomer ； Neurofibrillary tangle

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