The Inhibitory Effect of Hexamethonium Bromide as a Possible α7-nAChRs Antagonist in Controlling Nicotine-Induced Cell Proliferation in Non-Small Lung Cancer Cells

Yuhao Wang

《International Core Journal of Engineering》 7卷2期 (2021/02) Pp. 163-169

https://doi.org/10.6919/ICJE.202102_7(2).0021

摘要

Lung cancer is an urgent problem to the globe, and some of cases are highly connected to smoking according to the previous studies. Under this circumstance, nicotine plays a pivotal role in inducing and developing lung cancers especially in non-small lung cancer cells partially by elevating the expression of nAChRs, including α7-nAChRs. Therefore, inhibiting α7-nAChRs is a heated topic in treating lung cancers. One of the possible antagonist is called Hexamethonium bromide (C12H30Br2N2), which is a nicotine acetylcholine receptor antagonist. However, the specific mechanisms it triggers is still unknown. Hence, this paper reports possible results to three experiments that test hexamethonium's ability to inhibit non-small lung cancer cells proliferation, combine with α7-nAChRs as well as activate signaling pathways in the down-stream of α7-nAChRs.

關鍵字

α7-nAChRs ； Non-Small Lung Cancer Cells ； Hexamethomium Bromide ； Acetylcholine Receptor Antagonist ； Nicotine-Induced Proliferation

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