As the technology of civil engineering develops, many long-span cross-sea bridges are built frequently. These bridges contain many advanced civil engineering knowledge and technology, which is valuable for engineers to investigate. Hangzhou Bay Bridge is one of the most extraordinary long span cross-sea bridges in China. South Channel Bridge and North Channel are the most particular parts in this bridge, which are cable-stay bridges with A-shape tower and diamond-shape double towers respectively. This article aims to introduce and analyze the structure of the South Channel Bridge in Hangzhou Bay Bridge. Before the analysis, the background and basic information would be provided in the section of introduction. In the analysis section, first of all, the materials and construction process would be described. Secondly, the types of design loads and the calculation process would be presented. Thirdly, the analysis of loading situation is provided to indicate route of loads transferring and components reactions. In addition, there are vertical and horizontal structural analysis models would be showed in this article to reflect the loading situations more accurately. Finally, the conclusion would summarize the whole content of article and describe the advantages and weaknesses of South Channel Bridge. According to the comprehensive analysis, the South Channel Bridge is a steel box girder cable-stay bridge with a single A-shape Tower, which obtains the extraordinary stability and durability. However, it is difficult and expensive to construct and maintain the bridge. According to the investigation of South Channel Bridge in Hangzhou Bay Bridge, the engineers could learn the advanced civil engineering ideas and apply these advantages to their future design.