The high shear forces generated by dynamic cross-flow filtration are the ideal physical conditions to ensure continuous operation at sustainable high throughputs, and research on dynamic cross-flow filtration equipment has been a hot topic in the direction of membrane contamination. This paper used CFD (Computational Fluid Dynamics) numerical simulation to study the internal flow field distribution and membrane fouling of the vortex membrane separation device. The study found that the vortex membrane module generates a centrifugal shear flow field containing multiple secondary flows when rotating. The secondary flow in the vicinity of a rotating membrane module not only causes flow anomalies in the flow field in the vicinity of the membrane element, but also results in an uneven patchy distribution of shear forces on the membrane surface. In addition, the average shear force at the membrane surface increases with increasing speed, and the difference between the average shear force at the headwater and backwater surfaces is large, and this difference increases with increasing speed.