By application of the Fluent software, the forced surge-heave coupled oscillation of a 2D rectangular moonpool structure is simulated numerically. The influences of different oscillation frequencies, amplitudes and the ratios of the opening on the fluid forces on the moonpool are discussed. It is shown that, when the moonpool is under surge-heave coupled motion, the change of surging amplitude or frequency has different effects on the amplitudes and the waveform of time-history curve of each fluid force and moment, while, the change of heaving amplitude or frequency has only influences on the amplitudes of the vertical fluid force. The amplitudes and the waveform of time-history curve of the horizontal fluid force and moment are almost unaffected by the different ratios of the opening, while the amplitudes of the vertical fluid force decreases with the increase of the opening. The calculation results and the revealed phenomena have important significance for engineering design.