Selective catalytic reduction with NH_3 (NH_3-SCR) has been considered as the most successful denitration technology from stationary boilers and coal-fired plants. However, conventional commercial catalysts like V_2O_5-WO_3 (MoO_3)/TiO_2 show a series of drawbacks in practical applications, so developing novel catalytic is imperious. This paper begins by reviewing the latest TiO_2 based SCR catalysts. Then, it will go on to summarize three types of developed TiO_2 based catalysts, including pure TiO_2 as support catalysts, modification of TiO_2 as support catalysts and TiO_2 as active species catalysts. Firstly, although the species and content of interface-loaded active components are essential, the effect of interaction between species and supports on SCR reaction activity over TiO_2 supported has not been explored. Secondly, modification of TiO_2 as support catalysts mainly enhances a role of TiO_2 supported in activity and poisoning-resistant. However, the modification methods are limited to the doping of metal or nonmetal elements. Thirdly, titanium mainly regulates the strong oxidization of active species while its performance improvement on SCR is relatively limited. The challenges and opportunities for each type of catalysts are proposed while the effective strategies are summarized for developing novel TiO_2 based catalysts with high potential for industrial application. Some suggestions for future research are put forward, and TiO_2 based catalysts would be a fruitful area for further work. Hopefully, this review could make a little contribution to realize their commercial applications in the near future.