透過您的圖書館登入
IP:3.137.171.121
  • 期刊

Current Strategies and Challenges for Cancer Immunotherapy

摘要


Cancer immunotherapy is a drastic and crucial topic in the medical field since it acts a vital role in cancer treatment. As several types of clinical and preclinical strategies have been advanced by the scientists, which are designed to respond to different kinds of cancers situations, we are still plagued by some adverse side effects brought by those existing therapeutic tactics. In the following part, we would review the so-far development of cancer immunotherapy and discuss their characteristics and potency. Furthermore, we would critically posit the barriers for today's techniques and analyze immunotherapy's future prospects.

參考文獻


Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252–264 (2012).
Granier, C. et al. Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. ESMO Open 2, e000213 (2017).
Alsaab, H. O. et al. PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome. Front. Pharmacol. 8, 1–15 (2017).
Munn, D. H. & Bronte, V. Immune suppressive mechanisms in the tumor microenvironment. Curr. Opin. Immunol. 39, 1–6 (2016).
Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev. (2008)

延伸閱讀