The attack of congestive heart failure often acts on the patient's vagus nerve and sympathetic nerve, leading to the decline of cardiac regulation function, thereby inducing sudden death and other diseases. Although the traditional analysis method based on time and frequency domain has some feasibility, it ignores the physiological characteristics such as autonomic nervous rhythm. Therefore, this paper combined with information similarity method to analyze the characteristics of short-term fluctuation of heart rate in patients with chronic heart failure. By calculating the IBS index and the ratio of high and low frequencies of 98 patients and normal subjects, the results is analyzed and screened for significance. It is found that the IBS index of patients and normal subjects is significant (P <0.001), and the screening accuracy can reach 75%, and the sensitivity and specificity are maintained at a high level. In addition, when IBS index is combined with LH, the screening accuracy can reach 87.8%, which is increased by 9.2% compared with the traditional screening index LH. Therefore, IBS index provides a new perspective for the screening of CHF disease and has great clinical potential.