Role of CCR8 in Tumor Invasion and Metastasis

Shimin Zheng ； Qing Lv ； Zhiwei Bian

《International Core Journal of Engineering》 7卷10期 (2021/10) Pp. 52-55

https://doi.org/10.6919/ICJE.202110_7(10).0011

摘要

Chemokines induce leukocyte migration through the activation of chemokine receptors on the surface of leukocytes, a receptor for the chemokine I-309 in human monocytes. Death caused by malignant tumors is closely related to the metastasis of the tumor, and CCR 8 expressed in tumor cells combined to the corresponding chemokines can promote tumor invasion and metastasis, and can also play a pro-growth, anti-apoptotic role. This paper traces recent studies on the role and mechanisms of CCR8 during tumor invasion and metastasis, aiming to present existing results for reference for relevant studies and help establish new ideas.

關鍵字

CCR8 ； Malignant Tumor ； Invasion ； Metastasis ； Chemokines

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