In the ultra-deep well drilling project, the bottom hole temperature exceeds 200℃, the formation pressure is high, the bottom hole situation is complex, and drilling is difficult, which puts forward higher requirements for drilling fluid and drilling fluid additives. As one of the most important additives for water-based drilling fluid, fluid loss additive plays an important role in ensuring safe, fast and efficient drilling. Firstly, according to the performance requirements of high temperature and high salt resistance fluid loss additive for drilling fluid, AM/AMPS/SSS/NVP quadripolymer water-based fluid loss additive was synthesized by copolymerization for the first time. Performance evaluation shows that the fluid loss reducer can be used in 200℃/220℃ saturated brine drilling fluid, and can keep good rheology and low fluid loss.