In recent years, poor resource endowment and long-term impact of low oil prices have gradually become a common problem faced by China's petroleum industry, the traditional development mode and conventional technology has been difficult to achieve the efficient utilization of low-grade resources. During the 13th Five-Year Plan period of Jilin Oilfield, in order to cope with the problems of low oil price, high investment in production capacity construction and low-grade resources in the new area, Jilin Oilfield carried out the field test of intensive large multiwell cluster platform benefit construction and production in the low permeability reservoir represented by block ⅲ in Xinli oilfield and achieved remarkable results. The field practice of full reservoir pressure flooding, low cost and long-term lift, factory and clean operation has been carried out. The production of this block has achieved the goal of increasing production, increasing benefit, reducing investment and cost, established a new mode and supporting technology series of intensive large multiwell cluster benefit construction, production and development. It can open a new way for similar low permeability oil and gas resources benefit utilization in the future.