Objective: This article is to study the effect of different surface treatments of zirconia ceramics on the bond strength of the eighth-generation universal Single Bond Universal binder resin. Method: Cut the UPERCA Altron zirconia ceramic block into 4mm×4mm×2mm small pieces under a low-speed cutting machine, and divide them into 5 groups. A group: control group; B group: silane coupling agent treatment group; C group: sandblasting group; D group: sandblasting + 10-MDP treatment group; E group: sandblasting + silane coupling agent treatment group. Use Single Bond Universal adhesive to bond with Dentec DX. Flow light-curing fluid resin in a specific shape under the constraints of the mold. After 24 hours, the maximum shear force between each group of resin and zirconia ceramics was measured with a universal tester, Anti-shear strength was calculated, and the section was observed under a scanning electron microscope. Results: Anti-shear strength of the five groups are all ideal. There is no significant difference between group A and group B, group C, group D and group E, but there is a significant difference between group B and group C. Among them, the lowest is 18.3±2.69 (MPa) in group A, 21.85±6.57 (MPa) in group B, 30.43±5.61 (MPa) in group C, 27.91±4.21 (MPa) in group E, and the highest in group D is 32.17± 4.72 (MPa). All five groups of experimental data are statistically significant. Conclusion: When using Single Bond Universal adhesive, sandblasting can be used to simplify the clinical operation steps, and the ideal bonding effect can also be obtained. If the retention of the composite resin on the restoration is poor, it can be treated with 10-methylpropyl acyloxy sebacate (10-MDP) after sandblasting in clinical practice, and the bonding effect is the most ideal.