With the development of science and technology, the improvement of computer hardware performance and the influence of high-performance software, high-performance and high-sensitivity mice came into being. People who like to play games have higher requirements for mouse sensitivity and hope to achieve "zero" signal delay. This poses a challenge to the original mouse technology. The old-fashioned mouse cannot keep up with the response speed of the computer, and its performance is relatively poor. With the continuous development of wireless mouse (Bluetooth connection, WIFI connection) and USB3.0 wired mouse, all kinds of high-speed and low-cost single-chip microcomputers have poured into the market. A multifunctional "infinite" mouse is the original intention of this subject. This text is based on STM32 wireless mouse system design and realization, discusses the system function analysis, the hardware system design, the Kail development environment configuration, the multifunctional wireless mouse realization.