Objective To make a systematic review of blood pressure control and outcome in patients with myocardial infarction and heart failure. Methods Up to March 2021, we searched the published research reports of emergency department, ICU, EICU and ward of adults (over 18 years old). We included case-control, cohort, cross-sectional and observational studies to report the changes of physiological indicators and outcomes of patients with different treatment methods. Findings Of 1550 articles scanned, we included 15 studies from 8 countries and areas in the meta-analysis. The pooled studies included 153439 samples. β-adrenergic receptor blockers have a positive effect on the survival rate of patients with heart failure and myocarpal infection (non-direct association with myocarpal infection). In particularly, treatment with ACEI combined (OR = 0.68 [0.65, 0.70]). The use of β-adrenergic blockers, which effectively produces a protective effect, is a favorable factor. It was concluded that β-adrenergic blockers are recommended in patients with heart failure and myocardial infarction (not directly related to myocardial infarction) unless there are contraindications or serious adverse effects to either β-adrenergic blocker.