In order to predict the risk of aircraft conflict and enable controllers to make corresponding decisions accurately and quickly, an aircraft trajectory prediction model based on CNN-LSTM combined neural network is established in this paper. The longitude, latitude, height and heading characteristics of the track point in the future period are predicted, and compared with GRU, RNN and LSTM algorithms. The experimental results show that the CNN-LSTM combined neural network prediction model is better than other models, and the prediction error is the smallest. It can be used for controllers to find possible future anomalies of aircraft and carry out real-time warning.