With the coexistence of two channels, the operation among collecters, remanufacturers and wholesalers in the closed-loop logistics distribution network system is facing new challenges. At the same time, there are some problems such as the quality difference of collection inspection. In this case, considering the change of the quality difference of the double-channel collection inspection, a closed-loop logistics distribution network optimization model is constructed, aiming at maximizing the total operating income, and LINGO11.0 is applied to solve the problem, and the optimal transportation scheme and profit of supply chain members are given. By solving the model, the influence of the quality difference of collection inspection on the profit of supply chain members is further analyzed. The given model can choose a reasonable channel for the flow of used products, and effectively solve the operation optimization problems of collecters, remanufacturers and wholesalers.