Objective: To study the therapeutic effect of closed negative pressure suction technique in the treatment of orthopedic trauma as well as infected wounds and conventional dressing changes. Methods: Sixty patients with orthopedic trauma and infected wounds admitted to the hospital between January 2020 and December 2022 were selected and randomly grouped, and the treatment effects of the two groups were compared. Results: The various clinical effects of patients in the observation group were better than those in the control group (P < 0.05). Conclusion: The treatment of orthopedic trauma and infected trauma patients by closed negative pressure suction technology can improve the clinical effect and is worth promoting.