Sumerian civilization refers to the civilization that flourished in the middle and lower reaches of the Mesopotamia from about 4000 BC to the mid-18th century BC, which experienced the age of Jemdet Nasr, the age of Uruk, the City-state period, the era of Akkadian Empire, the age of Guti, the era of Ur III dynasty, and the last Isin-Larsa period. During the middle of the 18th century BC when Hammurabi united the Mesopotamia, the Sumerian civilization was inherited by Babylon and the Sumerian era was ended. This paper first expounds the origin of Sumerian civilization, and then discusses the myth of Sumerian civilization and the influence of myth on people’s life, thought, city-state and regime change in Mesopotamia.