Both vampires and Chinese female ghosts are imaginary beings from folklore, but they bear different images in literary works. Based on the vision that man is an integral part of nature, Chinese people seek harmony between man and nature, which generates a romantic relationship between man and female ghost in traditional folk tales. For another, the images of vampires have been omnipresent in western literary fictions, whose appearance and image are closely related to Christian doctrine and European humanism. This paper describes the literary image of vampires and Chinese female ghosts respectively, and analyzes the relationship between human and ghosts by comparing the differences between Chinese and western ghosts. It reveals that the differences of human‐ghost relationship actually reflect differences between Chinese and Western religious culture and philosophy thoughts.