Starting from the current situation of foreign trade in Anhui Province, this paper studies the hot issue of cross‐border e‐commerce promoting the transformation and upgrading of foreign trade in Anhui Province, focuses on the significance and promotion mechanism of cross‐border e‐commerce for the transformation and upgrading of foreign trade in Anhui Province, and analyzes the restrictive factors of cross‐border e‐commerce promoting the transformation and upgrading of foreign trade in Anhui Province, It also puts forward strategies and suggestions for developing cross‐border e‐commerce and promoting the transformation and upgrading of foreign trade in Anhui Province.