Application of Biotransformation Technology in Pharmaceutical

Lingmin Jiang ； Yuefang Luo

《International Journal of Social Science and Education Research》 5卷6期 (2022/06) Pp. 45-52

https://doi.org/10.6918/IJOSSER.202206_5(6).0007

摘要

The use of exogenous natural or synthetic organic compounds as a substrate, added to the growing state in the biological system or enzyme system, under appropriate conditions for culture, the substrate and the enzyme in the biological system interaction,resulting in Structure change,this process known as biotransformation, also known as biocatalysis, its essence is the enzyme catalytic reaction.Compared with chemical catalysts, biotransformation with high specificity, conditions are mild, selective, less by‐product and do not pollute the environment and so on. In recent years, biotransformation to structural modification of the chemical constituents of traditional Chinese medicine, novel structure, better lead compounds can be obtained, or are valuable intermediates.Biological transformation to the pharmaceutical industry in drug research and a series of ground‐breaking application creates enormous health and economic value, has become an effective way to develop new drugs.

關鍵字

Biotransformation ； Suspension culture ； Secondary metabolism ； Microbial transformation ； Enzymatic conversion

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