Regional clean government cultural resources are an important part of regional culture, bearing the profound wisdom and noble spiritual qualities of local sages who are honest in politics, serving the local area, and good in far‐sighted governance. It is of great practical significance for colleges and universities to fully understand and give full play to the important value of regional cultural resources of clean government in the construction of honesty culture in the new era, enrich the construction form, get rid of the development dilemma, and improve the actual effect of the construction. It is necessary to constantly change ideas, strengthen mechanism guarantee, make good use of high‐quality resources, innovate content and form, continuously promote the integration and application of regional cultural resources of clean government and the construction of clean culture in the new era of colleges and universities, and form a good situation of "mutual promotion and win‐win, prosperity and development".