Criterion of Liability in Infringement of Intellectual Property Right (IPR) has always been the topic of debate in academia. In practice, the law enforcement officers are often at a loss. The opinion of author is as followings: Infringement liability can be divided into injunctions and damages. Fault liability applies to injunctions, and no‐liability applies to damages. In order to figure out the criterion of liability in infringement of IPR, the author firstly introduce the meaning of criterion of liability in jurisprudence, which is the fundamental basis for all branches of law; then the author compares the IPR with proprietary rights, and concludes that IPR also have the right of the IPR claim, just the same as right of the real claim, combined with the characters of IPR, fault liability applies to injunctions. Finally, the author conclude that no‐liability applies to damages, however, the infringer takes the burden of proof.