Induction of Endogenous Cytokines by Traditional Chinese Medicine Leading to Reduction of Serum HBsAg Levels

傳統中醫藥誘生內源性細胞因子導致血清HBsAg水平之下降

陸庭譯(Ting-Yee Lok) ； 沈郁強(Yuh-Chiang Shen) ； 楊賢鴻(Sien-Hung Yang)

《中醫藥雜誌》 31卷1期 (2020/06) Pp. 66-83

https://doi.org/10.6940/JCM.202006_31(1).06

摘要

Chronic hepatitis B virus (HBV) infection continues to be a serious global health problem and current therapeutics seldom reach treatment endpoint of HBsAg seroclearance with or without Anti-HBs. In this report, it was observed that, formulated under the guiding principle of dynamic equilibrium of ying and yang, traditional Chinese medicine (TCM) treatment of chronic hepatitis B infection resulted in remarkable reduction of serum HBsAg levels. Clinical cytokine tests demonstrated that the patients who succeeded in having levels of serum HBsAg reduced were those tested to have endogenous cytokines IFN-α, IFN-γ, TNF-α and/or TGF-β_1 induced. Those cytokines are known to be able to trigger degradation of cccDNA, the HBV transcription template, in the nucleus of the infected hepatocyte noncytopathically. We conclude that TCM is a novel strategy to successfully treat chronic hepatitis B infection.

關鍵字

traditional Chinese medicine (TCM) ； chronic hepatitis B ； cccDNA ； endogenous cytokines

並列摘要

慢性B型肝炎病毒（HBV）感染持續為一種嚴重的世界性健康衛生問題，而現有的治療方案鮮能達致清除血清HBsAg，同時產生或未產生Anti-HBs的治療終點。本報告觀察到在陰平陽謐指導原則下，傳統中醫藥（TCM）治療慢性B型肝炎感染導致血清HBsAg水平顯著下降。細胞因子的臨床實驗表明血清HBsAg水平成功降低的病患即那些誘生了一種或多種內源性細胞因子IFN-α,IFN-γ,TNF-α及TGF-β_1。而那些細胞因子已知能導致受感染肝細胞核中的HBV複製模板cccDNA的降解，但不傷及肝細胞。我們因而論定TCM是一種能有效治療慢性B型肝炎感染的新穎策略。

並列關鍵字

傳統中醫藥 ； 慢性B型肝炎 ； 閉鎖環狀共價鍵去氧核醣核酸 ； 內源性細胞因子

參考文獻

World Health Organization. Fact Sheet-Hepatitis B, Available at: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b, Accessed July 18, 2018.

Lucifora J, Protzer U. Attacking hepatitis B virus cccDNA -- The holy grail to hepatitis B cure. Journal of Hepatology, 2016; 64: S41-S48.

Tajiri K, Shimizu Y. New horizon for radical cure of chronic hepatitis B virus infection. World J Hepatol., 2016; 8(21): 863-873.

Ward H, Tang L, Poonia B, Kottilil S. Treatment of hepatitis B virus: an update. Future Microbiol, 2016; 11(12): 1581-1597.

A Bertoletti, NL Bert. Immunotherapy for chronic hepatitis B virus infection. Gut Liver, 2018; 12(5): 497-507.