Based on a comprehensive analysis of the common problems in the cultivation of innovative and entrepreneurial postgraduates, this paper introduced the methods and effects of the cultivating mode through the industrial and education cooperation between universities and enterprises. Under this mode, the students take part in the whole process from laboratory research to workshop pilot test until industrial production, which not only strengthens the students' ability of theoretical exploration and application in the research field, but also make them understand well the knowledge of innovation and entrepreneurship such as project management and feasibility demonstration. Their ability to apply the research results to the production practice has been greatly improved.