In the process of regional economic development, urban agglomerations play an indispensable role. Among them, central cities play a prominent role and become the center and leader of urban agglomerations. Driving economic development through the development of urban agglomeration is an important way to realize regional economic development. Under the background of the rise of central China, the development of central plains urban agglomeration in the central and western regions of China becomes particularly important. In 2017, the central plains urban agglomeration development plan notice was officially issued and raised to a new height. This paper starts from the basic status quo of the central plains urban agglomeration and combines the relevant theories of the urban agglomeration and regional economy to continuously improve and optimize, so as to provide more effective Suggestions for the integrated high-quality development of the central plain's urban agglomeration.