In recent years, with the popularity and widespread use of the Internet, the wholesale and retail industry has entered a new period of development. New retail relies on the Internet and uses advanced technological tools such as big data and artificial intelligence to create a new online and offline sales model. This paper empirically analyzes the factors influencing the wholesale and retail industry in the context of new retailing, showing that logistics and Internet factors have a more significant impact on the wholesale and retail industry in the new retail mode. And through the analysis, it gives new development suggestions for the future wholesale and retail industry. The future development of wholesale and retail industry should focus on the Internet, reshape the business model, and carry out a new model of online and offline deeply integrated retail.