Innovation is a hot topic in contemporary society. In order to cultivate the students' creative quality, to open innovation entrepreneurship education in colleges and universities, this paper starting from the goal, to explore university creative education influence on college students' innovative entrepreneurial intention, thus can get innovative entrepreneurial behavior prediction research. SPSS22.0 software was used for descriptive statistical analysis, reliability and validity test, regression analysis, etc., to obtain relevant statistical test results, Innovation and entrepreneurship education has a significant positive impact on innovation and entrepreneurship intention; Innovation and entrepreneurship education has a significant positive impact on innovation and entrepreneurship intention.