Promoting the coordinated development of regional economy and constructing a scientific and reasonable development layout is an important guarantee for promoting the high-quality development of regional economy. Based on the input-output table, the regional industry-linked economic distance model is used to study the industry-linked economic distance of manufacturing industries in China at different technology levels within and between regions. It was found that: (1) the high-end manufacturing industry has the greatest degree of association and the shortest economic distance from its own sector, and the high-end manufacturing industry or the mid-range manufacturing industry has the greatest degree of association and the shortest economic distance from its own to the mid-range manufacturing industry; (2) the number of sectors with the largest forward correlation economic distance index between the high-end manufacturing industry and the middle and low-end manufacturing industry has increased, indicating that the promotion role of high-end manufacturing on the manufacturing industry has become more obvious; (3) low-end manufacturing has the greatest degree of association with its own sector and the shortest economic distance, construction and mid-range manufacturing has the greatest degree of association with mid-range manufacturing and the shortest economic distance, mid-range manufacturing, high-end manufacturing, electricity and heat supply and construction constitute the greatest degree of association with high-end manufacturing and the shortest economic distance, and high-end manufacturing pulls more industries. However, manufacturing industries of different technology levels are more closely linked within regions than between regions; manufacturing industries in the eastern coastal region drive the development of other regions as upstream industries, spatially showing a spoke shape centered on the eastern coast; low- and mid-range manufacturing industries in Beijing, Tianjin or the eastern coastal region showing a spoke shape centered on Beijing, Tianjin or the eastern coast, and high-end manufacturing industries in the northwest or northern coastal region showing a spoke shape centered on the northwest or northern coastal region.