With the development of the times, cultural and creative industries have become a new driving force for the development of the national economy with their characteristics of low pollution and high income. Bengbu is located in the Yangtze River Delta. In recent years, driven by the radiation of the surrounding areas, it has been developing cultural and creative industries. Therefore, studying the relationship between Bengbu's cultural and creative industries and regional economic development is of great significance to promoting the upgrading and transformation of regional industrial structure and promoting the sustainable development of regional economy. This paper expounds the current situation of cultural and creative industries and economic development in Bengbu City, and makes an empirical analysis of the relationship between cultural and creative industries and economic development in Bengbu City. It concludes that there is a close relationship between the economic development and cultural and creative industries in Bengbu City. Finally, based on the analysis of the research results, the corresponding countermeasures and suggestions are put forward.