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Periodontal Disease is Associated with Metabolic Syndrome - The Role of Peripheral Total and Differential Leukocyte Count-Related Metabolic Derangements
摘要
Objective: Periodontal disease (PD) is chronic inflammation that produces a local and systemic inflammatory response. PD has been reported to be a possible risk factor for some of the components of the metabolic syndrome (MetS), including obesity, diabetes, and dyslipidemia. The present study aimed to examine the relationship between PD and the MetS in a Chinese population, and also the possible mechanism of PD-related metabolic derangements. Methods: A total of 1,102 participants aged 54 ± 10 years were enrolled in this cross-sectional study, including 447 participants with PD and 655 participants without PD. The total and differential leukocyte profiles of peripheral blood were measured. Results: The participants with PD had higher rates of MetS and its components (central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, and impaired fasting glucose) than the participants without PD. In multiple logistic regression analysis, PD was independently associated with the MetS. In further analysis, the PD group had elevated circulating levels of total white blood cells (7.615 ± 2.781 vs. 7.146 ± 2.818 10^9/L), neutrophils (5303 ± 2929 vs. 4611 ± 2956 10^9/L), monocytes (472 ± 273 vs. 410 ± 265 10^9/L), and lymphocytes (1963 ± 927 vs. 1763 ± 906 10^9/L) than the participants without PD. In addition, total and differential leukocyte counts were significantly associated with PD, MetS, and its components (body mass index and high-density lipoprotein-cholesterol levels). Conclusions: PD was independently associated with the MetS in a Chinese population. Total and differential leukocyte counts were associated with PD-related metabolic derangements.
延伸閱讀
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