Cardiac arrest or circulatory collapse in patients undergoing spinal surgery is a rare but devastating event. Our case-series report showed that the overall incidence of intraoperative circulatory collapse was 0.074% in adult patients who received posterior lumbar surgery. According to our database, patients who developed intraoperative circulatory arrest were typically aged (mean age of 73 years), of low disease severity (ASA PS II-III) and without gender predominance. One patient developed postoperative stroke. The etiology of circulatory arrest during spine surgery is most likely multifactorial, including severe hypovolemia, electrolyte derangement, thromboembolic events, anaphylaxis, and anesthesia medication problems. Prospective clinical studies are needed to investigate the hemodynamics and hormonal hemostasis during posterior spinal fusion surgery.