台灣山羊黏多醣症基因型頻率

Frequency of caprine mucopolysaccharidosis IIID genotypes in Taiwan

林德育(Der-Yuh Lin) ； 陳若菁(Jo-Ching Chen) ； 黃鈺嘉(Yu-Chia Huang) ； 林炯仁(Jeong-Ren Lin) ； 陳坤照(Kuen-Jaw Chen) ； 陳水財(Shui-Tsai Chen) ； 莊璧華(Pi-Hwa Chuang) ； 吳明哲(Ming-Che Wu)

《畜產研究》 41卷3期 (2008/09) Pp. 213-220

摘要

檢測2912頭山羊之黏多醣症第三型（G6S）基因型，包括努比亞山羊1209頭、阿爾拜因山羊991頭、撒能山羊245頭、波爾山羊139頭、台灣黑山羊129頭、吐根堡山羊51頭、賴滿嬌山羊39頭、努比亞雜交山羊73頭、波爾雜交山羊18頭及阿爾拜因雜交山羊18頭。G6S正常型（AA）有94.1％（2741/2912），其中努比亞種有6頭為有病型（BB）及130頭為雜合型（AB）為最多，佔該品種的頻率有11.2％（136/1209）；而在阿爾拜因、撒能及波爾山羊亦發現有雜合型個體，此結果與國外報告不同，可能與各國登錄制度中，放寬級進到一定百分率可登錄為純種羊有關。正常型與雜合型的分佈在公母兩性別相近5.6％及6.0％。本試驗共有台灣41家養羊場參加，應用基因選種技術進行種羊選種，將有助於整體生產體系之效率提高。

關鍵字

山羊 ； 黏多醣症 ； 遺傳缺陷

並列摘要

Caprine mucopolysaccharidosis IIID, or N-acetylglucosamine 6-sulfatase deficiency(G6S), is a recessive inherited disorder of goat. There were 2912 goat DNA samples tested from 41 herds of 1209 Nubians, 991 Alpines, 245 Saanens, 139 Boers, 51 Toggenburgs, 129 Taiwan Black Goats and 39 LaManchas. The normal genotypes were only 94.1% in total. The heterozygote and defected Nubians was as high as 11.3%(136/1209), 6 defected and 130 heterozygote goats in 1209 Nubians. However, carriers were also found in other breeds. There were 2.0%, 0.8%, 1.4%, 7.8% and 1.4% heterzygotes found in Alpines, Saanens, Boars, Taiwan Black Goats and Nubian crossbreds, respectively. One of the possible reasons was that upgrading goats could be listed in several goats associations in the world. The carriers frequencies in male and female were 5.6% and 6.0%, respectively, and no association was found. In addition of the survey of the G6S frequency, genotype-assisted selection was practiced to improve the meat goat production efficiency in Taiwan.

並列關鍵字

Caprine ； Mucopolysaccharidosis ； Genetic deficiency